American Journal of Clinical Nutrition

  • The American Journal of Clinical Nutrition Reviewer Acknowledgments
    em Janeiro 11, 2022 a 12:00 am

    We thank the following individuals for taking the time necessary to evaluate original manuscripts. Anonymous, conscientious, fair, and timely peer review is the lifeblood of the journal.

  • Calendar of Events
    em Janeiro 11, 2022 a 12:00 am

    Due to the ongoing COVID-19 pandemic, events around the world are being postponed or moved online. For the most current information on events listed below, please visit the meeting's website.

  • Corrigendum to Razquin et al. Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet. Am J Clin Nutr 2021;114:1646–54
    em Janeiro 11, 2022 a 12:00 am

    Address correspondence to MM-G (e-mail:

  • Erratum to Ebbeling et al. Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia—a randomized controlled feeding trial. Am J Clin Nutr 2021;115(1):154–62
    em Janeiro 11, 2022 a 12:00 am

    Address correspondence to DL (e-mail:

  • Four weeks of spice consumption lowers plasma proinflammatory cytokines and alters the function of monocytes in adults at risk of cardiometabolic disease: secondary outcome analysis in a 3-period, randomized, crossover, controlled feeding trial
    por Oh E, Petersen K, Kris-Etherton P, et al. em Dezembro 4, 2021 a 12:00 am

    ABSTRACTBackgroundNumerous studies demonstrate acute anti-inflammatory properties of individual spices, but none have examined the effect of longer-term consumption of a spice blend incorporated in a meal.ObjectivesWe investigated the effect of longer-term spice consumption on inflammatory cytokines and monocyte subsets [classical (CM), intermediate (IM), nonclassical (NCM)] in adults at risk of cardiometabolic disease.MethodsA 3-period, randomized, crossover, controlled feeding trial was conducted. Participants (n = 71 recruited; n = 63 completed) randomly consumed diets differing in terms of the quantity of spices: 0.547 g (low-dose spice diet; LSD), 3.285 g (medium-dose spice diet; MSD), or 6.571 g (high-dose spice diet; HSD) · d−1 · 2100 kcal−1, for 4 wk with a ≥2-wk washout between diets. At baseline and after each diet period, proinflammatory cytokines (IL-1β, IL-6, IL-8, monocyte chemoattractant protein-1, and TNF-α) in plasma and LPS-stimulated peripheral blood mononuclear cell culture supernatants, and the phenotype and function of monocyte subsets, were measured in fasted participants. Postprandial proinflammatory cytokines also were quantified at baseline by consumption of a low-spice-dose test meal, and after each diet period by consumption of a test meal containing a spice dose corresponding to daily spice consumption during the preceding 4-wk diet period.ResultsFasting plasma IL-6 was reduced (mean ± SEM: −118.26 ± 50.63 fg/mL; P < 0.05) after MSD compared with baseline. Postprandial plasma IL-1β, IL-8, and TNF-α were lower (mean ± SEM : −9.47 ± 2.70 fg/mL, −0.20 ± 0.05 pg/mL, and −33.28 ± 12.35 fg/mL, respectively) after MSD compared with LSD (main diet effect; P < 0.05). CM adherence was reduced (mean ± SEM: −0.86 ± 0.34; P = 0.034) after HSD compared with LSD. IM migration was reduced after MSD and HSD compared with LSD (mean ± SEM: −0.39 ± 0.09 and −0.56 ± 0.14, respectively; P < 0.05).ConclusionsFour weeks of MSD consumption reduced fasting plasma IL-6 and postprandial plasma IL-1β, IL-8, and TNF-α as well as altering monocyte function.This trial was registered at as NCT03064932.

  • Well-defined interventions for nutritional studies: from target trials to nutritional modeling
    por Chiu Y. em Novembro 26, 2021 a 12:00 am

    American Heart Association10.13039/100000968#834106/Yu-Han Chiu/2021

  • Invitation for nominations and applications for 2022 Scientific Achievement Awards, the ASN Class of 2022 Fellows, and other honors
    em Novembro 23, 2021 a 12:00 am

    Address correspondence to MC (E-mail:

  • Is high dietary quality the real fountain of youth?
    por Wright M, Widen E. em Novembro 23, 2021 a 12:00 am

    NIH10.13039/100000002National Institute of Nursing Research10.13039/100000056K01NR017903

  • Sustainable food systems and nutrition in the 21st century: a report from the 22nd annual Harvard Nutrition Obesity Symposium
    por Fanzo J, Rudie C, Sigman I, et al. em Novembro 9, 2021 a 12:00 am

    ABSTRACTFood systems are at the center of a brewing storm consisting of a rapidly changing climate, rising hunger and malnutrition, and significant social inequities. At the same time, there are vast opportunities to ensure that food systems produce healthy and safe food in equitable ways that promote environmental sustainability, especially if the world can come together at the UN Food Systems Summit in late 2021 and make strong and binding commitments toward food system transformation. The NIH-funded Nutrition Obesity Research Center at Harvard and the Harvard Medical School Division of Nutrition held their 22nd annual Harvard Nutrition Obesity Symposium entitled “Global Food Systems and Sustainable Nutrition in the 21st Century” in June 2021. This article presents a synthesis of this symposium and highlights the importance of food systems to addressing the burden of malnutrition and noncommunicable diseases, climate change, and the related economic and social inequities. Transformation of food systems is possible, and the nutrition and health communities have a significant role to play in this transformative process.

  • Portion size can be used strategically to increase intake of vegetables and fruits in young children over multiple days: a cluster-randomized crossover trial
    por Roe L, Sanchez C, Smethers A, et al. em Outubro 28, 2021 a 12:00 am

    ABSTRACTBackgroundAlthough dietary guidelines recommend that vegetables and fruits make up half the diet, it is unclear whether serving vegetables and fruits in larger portions will have sustained effects on children's intake over multiple days.ObjectivesThis study tested the effects on children's intake of 2 strategies for increasing the proportion of vegetables and fruits: either adding or substituting extra portions as side dishes at meals and snacks over 5 d.MethodsIn a cluster-randomized crossover design with 3 periods, we provided all meals and snacks for 5 d to 53 children aged 3–5 y in classrooms in their childcare centers. In the Control condition, we served typical portions for all food groups. In the Addition condition we increased portions of low-energy-dense vegetables and fruits by 50%, and in the Substitution condition we increased portions of vegetables and fruits by 50% and also reduced portions of other foods by an equivalent weight.ResultsFor vegetables, the Addition strategy increased daily intake compared with Control by 24% (mean ± SEM = 12 ± 3 g/d; P = 0.0002), and the Substitution strategy increased intake compared with Control by 41% (22 ± 3 g/d; P < 0.0001). For fruits, consumption increased by similar amounts: Addition by 33% (60 ± 6 g/d) and Substitution by 38% (69 ± 8 g/d; both P < 0.0001). Both strategies increased vegetable and fruit intakes compared with Control across all 5 days (all P < 0.004), although the increase in fruit consumption with Addition declined over time (P < 0.0001). Daily energy intake compared with Control increased by 5% with Addition (57 ± 17 kcal; P = 0.001) but decreased by 6% with Substitution (−64 ± 21 kcal; P = 0.004).ConclusionsBoth the Addition and Substitution strategies promoted increases in vegetable and fruit intake over 5 d in preschool children. When excess energy intake is a concern, substituting vegetables and fruits for other foods is a better option than simply serving more.This trial was registered at as NCT03242863 (, where the protocol is available.

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